In the category of veterinary oral medications, antibiotics are unquestionably the largest class. From a therapeutic perspective, antibiotics are considered etiological treatment drugs as they directly target the microorganisms causing the disease. However, in addition to antibiotics, a perfect veterinary prescription also requires symptomatic medications. Symptomatic drugs can play an irreplaceable role in enhancing the effectiveness and completeness of treatment from a different angle, complementing the etiological drugs. This is the integration of etiological and symptomatic treatments!

Despite this, the number and variety of symptomatic treatments in veterinary chemical drugs are still relatively few and cannot compare with antibiotics. Some things are strangely valued more simply because they are rare. Today, we are discussing calcium caberate, one of the few oral antipyretic and analgesic drugs in veterinary medicine. While its clinical application is not widespread, when used correctly in certain prescriptions, it can have a potent synergistic effect.

Although we highlight the benefits of calcium caberate, it is not without its drawbacks. After all, everything has two sides. Therefore, when used correctly, calcium caberate can be an effective therapeutic agent. However, improper use can lead to serious side effects, even acute death. The following are the contraindications for the use of calcium caberate:

For example, calcium caberate is an organic acid, and its aqueous solution is acidic. If calcium caberate is combined with glucocorticoid drugs like dexamethasone phosphate or prednisone acetate, it can reduce the resistance of the gastric and duodenal mucosa in livestock to stomach acid, which can lead to increased gastrointestinal bleeding.

Additionally, due to the acidic nature of calcium caberate, it must not be used in combination with antacid medications such as sodium bicarbonate (baking soda), potassium bicarbonate, and sodium carbonate. These antacids can increase the excretion of calcium caberate through the urine, leading to a decrease in blood drug concentration, making their concurrent use inadvisable.

Third, because of the acidic nature of calcium caberate, it should not be combined with alkaline drugs. Since the solution of calcium caberate is acidic, mixing it with alkaline medications can cause an acid-base neutralization reaction, which degrades the drug and significantly reduces its clinical efficacy. Alkaline drugs in the veterinary market include sodium sulfadimethoxine, sodium sulfamethoxazole, sodium sulfachlorpyridine, and sodium sulfamethazine.

Therefore, calcium caberate should be avoided in combination with these alkaline drugs to prevent the reduction of its clinical effectiveness.

Lastly, one important consideration when using calcium caberate is to avoid combining it with certain antibiotics, such as tetracycline, oxytetracycline, doxycycline, tylosin, tiamulin, and enrofloxacin. While there is no antagonistic interaction, conflicting mechanisms, or acid-base neutralization, these antibiotics can form complexes with calcium caberate, reducing its solubility and causing the solution to become cloudy.

Moreover, this can also decrease the dissolution rate of the drug in the body, leading to slower onset and reduced effectiveness. Therefore, when using calcium caberate as an antipyretic, it is crucial to understand its compatibility and contraindications, and avoid combining it with the aforementioned drugs. If combination therapy is required, it is advisable to avoid mixing the drugs together (it is better to use them separately). Alternatively, replace it with other antipyretic drugs that do not interact with other medications in the prescription, such as acetaminophen, aminopyrine, or compound aminopyrine.