Tildipirosin is a broad-spectrum antibacterial drug that has antibacterial activity against both Gram positive and Gram negative bacteria. It is particularly sensitive to pathogens that cause respiratory diseases in pigs and cows, such as Actinobacteria pleuropneumoniae, Pasteurella multocida, Bordetella bronchisepticus, Haemophilus parasuis, as well as hemolytic Mannheim and sleep tissue loving bacteria.