Sulphaguanidine

Sulphaguanidine

Sulphaguanidine is a specialized sulfonamide antibiotic distinguished by its unique pharmacokinetic property: it is poorly absorbed from the gastrointestinal tract. Unlike other sulfa drugs designed for systemic circulation, Sulphaguanidine remains concentrated within the intestine, making it exceptionally effective for the local treatment of enteric infections. It acts against susceptible Gram-negative and Gram-positive bacteria, including Escherichia coli, Salmonella, and Shigella species. This "local action" makes it a premier choice for treating bacterial enteritis, bacillary dysentery, and neonatal diarrhea in livestock. Available commonly as oral powders, tablets, and boluses, it provides a targeted therapeutic approach to digestive health without placing significant stress on the animal's systemic organs.

FAQ（Sulphaguanidine）

1. What is Sulphaguanidine used for?
It is primarily used for the local treatment of gastrointestinal infections, such as bacterial enteritis, bacillary dysentery, and diarrhea in livestock.

2. How is Sulphaguanidine administered?
It is administered orally, typically mixed into feed or water as a powder, or given directly in the form of tablets or boluses.

3. Which animals can use Sulphaguanidine?
It is widely used for cattle, sheep, goats, pigs, and poultry; it is also occasionally used for companion animals like dogs to treat intestinal infections.

4. Is Sulphaguanidine safe for livestock?
Yes, it is considered very safe because it is poorly absorbed into the bloodstream, resulting in low systemic toxicity compared to other sulfonamides.

5. Can Sulphaguanidine be used preventively?
Yes, it is often used metaphylactically in feed or water to prevent enteric bacterial outbreaks, particularly during weaning or periods of high stress.