Sulphadiazine

Sulphadiazine

Sulphadiazine is a highly effective, short-to-intermediate-acting sulfonamide antibiotic used extensively in veterinary medicine. It is renowned for its rapid absorption and excellent tissue penetration, including its ability to cross the blood-brain barrier, making it valuable for treating systemic infections. While effective on its own against a broad spectrum of Gram-positive and Gram-negative bacteria (such as Streptococcus, Staphylococcus, and E. coli), it is most frequently combined with Trimethoprim (TMP). This combination creates a powerful synergistic effect that is bactericidal rather than just bacteriostatic. Sulphadiazine is commonly used to manage urinary tract infections, respiratory diseases, and wound infections in livestock and horses. Available in oral forms like boluses, tablets, and pastes, it offers a reliable solution for controlling bacterial diseases.

FAQ（Sulphadiazine）

1. What is Sulphadiazine used for?
It is primarily used to treat urinary tract infections, respiratory infections (pneumonia), gut infections, and meningitis caused by susceptible bacteria; it is widely used in combination with Trimethoprim.

2. How is Sulphadiazine administered?
It is typically administered orally in the form of tablets, boluses, or oral suspensions/pastes (especially in horses); injectable forms are available but often use the sodium salt.

3. Which animals can use Sulphadiazine?
It is widely used for horses, cattle, sheep, pigs, and companion animals (dogs and cats).

4. Is Sulphadiazine safe for livestock?
Yes, it is generally safe when used as directed. However, maintaining adequate hydration is crucial to prevent crystalluria (kidney stones), a known risk with sulfonamides.

5. Can Sulphadiazine be used preventively?
Yes, it can be used metaphylactically to control bacterial outbreaks in herds or flocks, particularly when combined with Trimethoprim to broaden its spectrum and efficacy.