Many friends will ask, what is the difference between oxytetracycline and oxytetracycline hydrochloride?
Oxytetracycline, also known as oxytetracycline soil alkali, is a soil alkali raw material
Oxytetracycline hydrochloride is the hydrochloride salt of oxytetracycline and is the finished product of oxytetracycline.
Oxytetracycline hydrochloride is stable and irritating.
All belong to the tetracycline class of antibiotics and broad-spectrum bacteriostatic agents.
Veterinary oxytetracycline is widely used in poultry and aquaculture as a disease prevention, feed additive and disease treatment. The functional efficacy of the two is comparable, but oxytetracycline hydrochloride is stable and the efficacy is more obvious, so the production cost is also higher.
Oxytetracycline is more commonly used by feed manufacturers in the market. It is also commonly used as a feed drug additive, which can not only prevent and treat diseases to a certain extent, but also improve feed utilization efficiency and promote weight gain. Oxytetracycline hydrochloride is used more in veterinary drug manufacturers!
To put it simply, oxytetracycline is mainly used for preventive functions, and oxytetracycline hydrochloride is mainly used for treatment! However, in animals that are not regularly medicated, oxytetracycline has also been used in many cases!
Let's take a look at the functions and benefits of the two:
oxytetracycline
Characteristics: This product is light yellow crystalline or amorphous powder. Content: ≥98%
Pharmacological action: broad-spectrum antibiotic. It has inhibitory effect on gram-positive and negative bacteria, rickettsia, mycoplasma, chlamydia, spirochetes, actinomycetes and amoebic protozoa. The principle of antibacterial mainly acts on the nucleoproteosome of the cell, inhibits the formation of peptide chains, impairs the synthesis of proteins in the cell, and produces antibacterial effects.
Functional indications
Broad-spectrum antimicrobial drug, proven by a large number of clinical and antimicrobial susceptibility experiments.
1. It has obvious curative effect on paratyphoid, epierythrocyte body, anthrax, asthma, dysentery and porcine lung disease in pigs.
2. Chick dysentery, chlamydia, can also be used to alleviate stress response, improve egg production, promote young poultry weight gain, etc.
3. This product prevents and treats various bacterial diseases of fish, such as: vibriosis, pseudomonocytic disease, Edwards' disease, streptococcal disease, and nocardiosis.
4. Sea cucumbers cause explosive epidemics due to bacteria, molds, viruses, etc., such as skin (ulceration), swollen mouth, spitting intestines, shaking head and other diseases;
It also has a good prevention and control effect on the disease of juvenile ginseng; It has obvious effects on rotten edge disease and rotten stomach disease in the seedling stage.
5. Red leg disease, gill rot and crustacean ulcer disease of shrimp and ulcer disease, limb rot disease and edema disease of crab have therapeutic effects.
Oxytetracycline hydrochloride
Characteristics: This product is a yellow crystalline powder, bitter taste, soluble in water. Content: ≥98%
1. It has obvious curative effect on paratyphoid, epierythrocyte body, anthrax, asthma, dysentery, and swine lung disease in pigs.
4. Sea cucumbers cause explosive epidemics due to bacteria, molds, viruses, etc., such as skin (ulceration), swollen mouth, spitting intestines, shaking head and other diseases; It also has a good prevention and control effect on the disease of juvenile ginseng; It has obvious effects on rotten edge disease and rotten stomach disease in the seedling stage.
There is a big difference that oxytetracycline hydrochloride is more soluble in water and can be used for oral and injection use, while oxytetracycline is less soluble in water and is usually mixed in feed accompaniment!
Dosage
Poultry: drinking water: 0.1 grams ~ 0.2 grams of this product are added to each kilogram of water, and the concentrated drinking effect is good; Mixing: Add 0.2 grams ~ 0.3 grams of this product per kilogram of feed, double for severe cases or follow the doctor's instructions.
Livestock: drinking water: 0.05 grams ~ 0.1 grams of this product are added to each kilogram of water, and the concentrated drinking effect is good; Mixing: Add 0.1 grams ~ 0.2 grams of this product per kilogram of feed, double for severe cases or follow the doctor's instructions.
Aquatic products: mixing: 0.5 grams ~ 1 gram of this product per kilogram of feed; Whole pool sprinkling: use 1 gram ~ 2 grams of this product per cubic water body; Depending on the breed and disease, it will be increased or decreased as appropriate.
Drug interactions
(1) When used in combination with sodium bicarbonate, it may increase the pH value in the stomach, and reduce the absorption and activity of tetracyclines.
(2) When used with calcium salts, iron salts or drugs containing metal ions calcium, magnesium, aluminum, bismuth, iron, etc. (including Chinese herbal medicines), it can form insoluble complexes with tetracyclines to reduce the absorption of drugs. (3) It can be used in combination with strong diuretics such as futimi, which can aggravate renal damage
(4) Tetracyclines are fast-acting bacteriostatic drugs, which can interfere with the bactericidal effect of penicillins on the bacterial reproduction period, so it is advisable to avoid using them together.
caution
(1) This product should be protected from light and sealed and stored in a cool and dark dry place. Avoid sun exposure. Do not mix with tap water and alkaline solutions with high chlorine content. Do not use metal containers to hold medicines.
(2) Avoid using dairy products and drugs containing calcium, magnesium, aluminum, iron, bismuth and feed with high calcium content when taking it internally. Food can block the absorption of tetracyclines and should be taken on an empty stomach before feeding.
(3) Adult ruminants, equine animals and rabbits should not take tetracyclines internally, because they are easy to cause digestive disorders, resulting in symptoms such as food reduction, bloating, diarrhea and vitamin B and K deficiency. Long-term application can induce superinfection of drug-resistant bacteria and fungi, and in severe cases, cause sepsis and death. Horses can sometimes develop gastroenteritis after injection, so it should be used with caution.
(4) Tetracyclines should not be used when the liver and kidney function of livestock are seriously damaged.
(5) During the physical medicine period, it is forbidden to take cattle and sheep internally every day, and it is forbidden during the milking period; Pig 5th. Injection of cattle 22nd. Forbidden during the milking period; Pig 20 days.